Atopy, airway responsiveness, and genes.
نویسندگان
چکیده
منابع مشابه
Atopy, airway responsiveness, and genes.
Asthma is a manifestation of bronchial hyperreactivity (BHR) and forms part of the spectrum of atopic disease. Some pedigree studies of atopy have suggested linkage with the high-affinity IgE receptor (FcE RI1) gene on chromosome 11q13, but others find no linkage. The molecular genetics of asthma and BHR have not been studied in the general population. We examined the genetic linkage of the Fce...
متن کاملParental and neonatal risk factors for atopy, airway hyper-responsiveness, and asthma.
BACKGROUND Previous studies have not resolved the importance of several potential risk factors for the development of childhood atopy, airway hyperresponsiveness, and wheezing, which would allow the rational selection of interventions to reduce morbidity from asthma. Risk factors for these disorders were examined in a birth cohort of 1037 New Zealand children. METHODS Responses to questions o...
متن کاملMeasuring exhaled nitric oxide levels in adults: the importance of atopy and airway responsiveness.
BACKGROUND Raised exhaled nitric oxide (Feno) levels have been associated with asthma. However, we have found that in children, Feno was increased in atopic children with increased airway responsiveness (AR), and this was independent of a diagnosis of asthma. STUDY OBJECTIVES The current study was designed to test the hypothesis that in adults there is no association between Feno and asthma a...
متن کاملLongitudinal predictors of airway responsiveness to distilled water: the role of atopy and maternal smoke exposure.
Airway responsiveness is an objectively measurable clinical trait related to the presence of asthma. Although risk factors for this trait have been evaluated cross-sectionally, little is known about its longitudinal predictors. A population cohort of 539 children, aged 8 yrs at the start of follow-up, underwent 3-7 bronchial challenge tests spaced at 3-9 month intervals. Airway responsiveness w...
متن کاملExhaled nitric oxide and asthma: complex interactions between atopy, airway responsiveness, and symptoms in a community population of children.
BACKGROUND Exhaled nitric oxide (FE(NO)) is raised in asthmatic children, but there are inconsistencies in the relationship between FE(NO) and characteristics of asthma, including atopy, increased airway responsiveness (AR), and airway inflammation. The aim of this study was to investigate the relationship between FE(NO) and asthma, atopy, and increased AR in children. METHODS One hundred and...
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ژورنال
عنوان ژورنال: Thorax
سال: 1996
ISSN: 0040-6376
DOI: 10.1136/thx.51.suppl_2.s55